Ammonia → HCID 59234740, compound

HRID 2040821Notes

Reaction equation

HRID 2040821 reaction equation
[CH2:1]([C:3]1[CH:8]=[C:7]([C:9]2[O:13][N:12]=[C:11]([C:14]3[CH:19]=[C:18]([CH3:20])[C:17]([O:21][CH2:22][C@@H:23]4[CH2:25][O:24]4)=[C:16]([CH2:26][CH3:27])[CH:15]=3)[N:10]=2)[CH:6]=[C:5]([CH3:28])[N:4]=1)[CH3:2].[NH3:29]>CO>[NH2:29][CH2:25][C@@H:23]([OH:24])[CH2:22][O:21][C:17]1[C:18]([CH3:20])=[CH:19][C:14]([C:11]2[N:10]=[C:9]([C:7]3[CH:6]=[C:5]([CH3:28])[N:4]=[C:3]([CH2:1][CH3:2])[CH:8]=3)[O:13][N:12]=2)=[CH:15][C:16]=1[CH2:26][CH3:27]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86639883HCID 86639883, compound

Product 1

HCID 59234740HCID 59234740, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(S)-2-ethyl-4-[3-(3-ethyl-5-methyl-4-oxiranylmethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-6-methyl-pyridine is treated with ammonia in MeOH as described in Example 46 step b) to give (R)-1-amino-3-{2-ethyl-4-[5-(2-ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-propan-2-ol.

Sources & evidence

ORD record
ord-0f2533466d32475bb7fcf7afb8243485
Source dataset
uspto-grants-2013_11
Patent number
US08580824B2

Reaction notes

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