HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-6-methylpyridine → 8-(6-Methyl-3-nitropyridin-2-yl)-3-(pyridin-2-ylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-6-methylpyridine | HCID 79205 | — |
| Reactant | 6-Methyl-2-(4-methylene-1-piperidyl)-3-nitropyridine | HCID 57493810 | — |
| Product | 8-(6-Methyl-3-nitropyridin-2-yl)-3-(pyridin-2-ylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene | HCID 56645678 | 49.6% |
Reaction Steps
The title product was prepared replacing 2-iodopyridine for 2-bromo-6-methylpyridine following the procedure reported above for the compound of Example 3. Purification of the residue by automated flash liquid chromatography (Horizon®TM-Biotage) (Petroleum Ether-EtOAc gradient from 9:1 to 4:6). Yield: 49.6%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-06f3761db6d54a1db5b477fdd8dc0f85 |
| Source note | uspto-grants-2013_11 |