反应详情

The title compound was synthesised following the method described here for Compound 2a using 1-Boc-3-pyrrolidinone instead of 1-(3-nitro-2-pyridyl)-4-oxopiperidine. After the usual work-up procedure, the crude product was purified by automated flash chromatography (Horizon®TM-Biotage) eluting with a Petroleum Ether-EtOAc gradient from 95:5 to 7:3, yielding the title compound as brownish oil. Yield: 75.8%.

1. customThe title compound was synthesised
2. customAfter the usual work-up procedure, the crude product was purified by automated flash chromatography (Horizon®TM-Biotage)
3. washeluting with a Petroleum Ether-EtOAc gradient from 95:5 to 7:3