HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-oxopyrrolidine-1-carboxylate → tert-Butyl 3-methylidenepyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-oxopyrrolidine-1-carboxylate | HCID 471360 | — |
| Reactant | 2-(4-Methylene-1-piperidyl)-3-nitropyridine | HCID 57493809 | — |
| Product | tert-Butyl 3-methylidenepyrrolidine-1-carboxylate | HCID 15297967 | — |
Reaction Steps
The title compound was synthesised following the method described here for Compound 2a using 1-Boc-3-pyrrolidinone instead of 1-(3-nitro-2-pyridyl)-4-oxopiperidine. After the usual work-up procedure, the crude product was purified by automated flash chromatography (Horizon®TM-Biotage) eluting with a Petroleum Ether-EtOAc gradient from 95:5 to 7:3, yielding the title compound as brownish oil. Yield: 75.8%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-4124b675ff494923995d5d1e4b097df0 |
| Source note | uspto-grants-2013_11 |