3-(3-Chlorophenyl)prop-2-ynal oxime → 3-(3-Chlorophenyl)-N-hydroxy-prop-2-ynimidoyl chloride

HRID 2040863Notes

Reaction equation

HRID 2040863 reaction equation
[OH:1][N:2]=[C:3]([Cl:10])[C:4]#[C:5][Si](C)(C)C.[Cl:11][C:12]1[CH:13]=[C:14](C#CC=NO)[CH:15]=[CH:16][CH:17]=1>>[Cl:11][C:12]1[CH:17]=[C:16]([C:5]#[C:4][C:3]([Cl:10])=[N:2][OH:1])[CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 765430563-(3-Chlorophenyl)prop-2-ynal oximeHCID 86662874N-Hydroxy-3-trimethylsilyl-prop-2-ynimidoyl chloride

Product 1

HCID 866628753-(3-Chlorophenyl)-N-hydroxy-prop-2-ynimidoyl chlorideYield 96.4%

Procedure

The title compound was prepared following the method herein described for Compound 3b, using Compound 31e instead of 3-trimethylsilylprop-2-ynal oxime. The pale brown residue was used in the next step without further purification. Yield: 96.4%.

Workup

  1. customThe pale brown residue was used in the next step without further purification

Sources & evidence

ORD record
ord-03511dc42bd04cd281104ee0cfc30fe2
Source dataset
uspto-grants-2013_11
Patent number
US08580962B2

Reaction notes

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