3-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene → 7-(Phenylethynyl)-5-oxa-2,6-diazaspiro[3.4]oct-6-ene

HRID 2040868Notes

Reaction equation

HRID 2040868 reaction equation
C1(C#CC2CC3(CCNCC3)ON=2)C=CC=CC=1.[C:19]1([C:25]#[C:26][C:27]2[CH2:41][C:30]3([CH2:33][N:32](C(OC(C)(C)C)=O)[CH2:31]3)[O:29][N:28]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(Cl)(Cl)Cl>[C:19]1([C:25]#[C:26][C:27]2[CH2:41][C:30]3([CH2:33][NH:32][CH2:31]3)[O:29][N:28]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 574938083-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-eneHCID 57493839tert-Butyl 7-(phenylethynyl)-5-oxa-2,6-diazaspiro[3.4]oct-6-ene-2-carboxylate

Product 1

HCID 574938407-(Phenylethynyl)-5-oxa-2,6-diazaspiro[3.4]oct-6-eneYield 100%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was synthesized following the method reported for Compound 1c, substituting Compound 1b with Compound 38a and running the reaction in chloroform. The crude brownish oily residue was used without further purification in the next reaction step. Yield: 100%.

Workup

  1. customThe crude brownish oily residue was used without further purification in the next reaction step

Sources & evidence

ORD record
ord-f1dacd33753e403ba57171374c9860c1
Source dataset
uspto-grants-2013_11
Patent number
US08580962B2

Reaction notes

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