3-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene → HCID 57493844, compound

HRID 2040870Notes

Reaction equation

HRID 2040870 reaction equation
C1(C#CC2CC3(CCNCC3)ON=2)C=CC=CC=1.[F:19][C:20]1[CH:21]=[C:22]([C:26]#[C:27][C:28]2[CH2:42][C:31]3([CH2:34][N:33](C(OC(C)(C)C)=O)[CH2:32]3)[O:30][N:29]=2)[CH:23]=[CH:24][CH:25]=1>C(Cl)(Cl)Cl>[F:19][C:20]1[CH:21]=[C:22]([C:26]#[C:27][C:28]2[CH2:42][C:31]3([CH2:34][NH:33][CH2:32]3)[O:30][N:29]=2)[CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 574938083-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-eneHCID 57493843HCID 57493843, compound

Product 1

HCID 57493844HCID 57493844, compoundYield 33.4%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was synthesized following the method reported for Compound 1c, substituting Compound 1b with Compound 40a and running the reaction in chloroform. The crude brownish oily residue was used without further purification in the next reaction step. Yield: 33.4%.

Workup

  1. customThe crude brownish oily residue was used without further purification in the next reaction step

Sources & evidence

ORD record
ord-b3dbb826cef843febde5e66b9d16f62d
Source dataset
uspto-grants-2013_11
Patent number
US08580962B2

Reaction notes

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