HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Methylidene-1,4-dioxaspiro[4.5]decane → HCID 56646683, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Methylidene-1,4-dioxaspiro[4.5]decane | HCID 10953743 | — |
| Reactant | Tert-butyl 3-(phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-8-carboxylate | HCID 57493807 | — |
| Product | HCID 56646683 | HCID 56646683 | 44.9% |
Reaction Steps
The title compound was synthesized using the same method described for Compound 1b but using Compound 31a instead of N-Boc-4-methylenepiperidine. After the usual work-up procedure, the title product was purified by automated RP chromatography (Isolera®TM-Biotage; gradient buffer NH4HCO3-MeCN from 40-60 a 20-80. Yield: 44.9%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-2f66bd1b8c8e4ef7844311e0afe854de |
| Source note | uspto-grants-2013_11 |