3-[(3-Chlorophenyl)ethynyl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-one → 3-(2-Phenylethynyl)-1-oxa-2-azaspiro[4.5]dec-2-en-8-one

HRID 2040872Notes

Reaction equation

HRID 2040872 reaction equation
Cl[C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH2:14][C:13]3([CH2:19][CH2:18][C:17](=[O:20])[CH2:16][CH2:15]3)[O:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1.C1(C#CC2CC3(CCC4(OCCO4)CC3)ON=2)C=CC=CC=1>>[C:4]1([C:8]#[C:9][C:10]2[CH2:14][C:13]3([CH2:19][CH2:18][C:17](=[O:20])[CH2:16][CH2:15]3)[O:12][N:11]=2)[CH:5]=[CH:6][CH:7]=[CH:2][CH:3]=1

Participants

3

Reactant 2

HCID 566464673-[(3-Chlorophenyl)ethynyl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-oneHCID 56646683HCID 56646683, compound

Product 1

HCID 566466843-(2-Phenylethynyl)-1-oxa-2-azaspiro[4.5]dec-2-en-8-one

Procedure

The title compound was synthesized using the same method described for the compound of Example 32, but starting from the compound of Example 44 instead of the compound of Example 31. The crude was purified by automated flash chromatography (SP1®TM-Biotage; Petroleum Ether-EtOAc 8:2) to give the title product as white solid. Yield: 80%.

Workup

  1. customThe title compound was synthesized
  2. customThe crude was purified by automated flash chromatography (SP1®TM-Biotage; Petroleum Ether-EtOAc 8:2)

Sources & evidence

ORD record
ord-3bf756c993954164bdc2a7b6f407dfbc
Source dataset
uspto-grants-2013_11
Patent number
US08580962B2

Reaction notes

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