HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[(3-Chlorophenyl)ethynyl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-one → 3-(2-Phenylethynyl)-1-oxa-2-azaspiro[4.5]dec-2-en-8-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[(3-Chlorophenyl)ethynyl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-one | HCID 56646467 | — |
| Reactant | HCID 56646683 | HCID 56646683 | — |
| Product | 3-(2-Phenylethynyl)-1-oxa-2-azaspiro[4.5]dec-2-en-8-one | HCID 56646684 | — |
Reaction Steps
The title compound was synthesized using the same method described for the compound of Example 32, but starting from the compound of Example 44 instead of the compound of Example 31. The crude was purified by automated flash chromatography (SP1®TM-Biotage; Petroleum Ether-EtOAc 8:2) to give the title product as white solid. Yield: 80%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-3bf756c993954164bdc2a7b6f407dfbc |
| Source note | uspto-grants-2013_11 |