HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxaspiro[4.5]decan-8-one → 8-Methylenespiro[4.5]decane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxaspiro[4.5]decan-8-one | HCID 567415 | — |
| Reactant | 8-Methylidene-1,4-dioxaspiro[4.5]decane | HCID 10953743 | — |
| Reactant | Spiro(4.5)decan-8-one | HCID 14626805 | — |
| Product | 8-Methylenespiro[4.5]decane | HCID 57493856 | — |
Reaction Steps
The title compound was prepared following the method reported here for Compound 31a. As starting material spiro[4.5]decan-8-one replaced 1,4-dioxaspiro[4.5]decan-8-one. After the usual work-up procedure, the residue was purified by means of automated flash chromatography (SP01®M-Biotage; CH2Cl2) to give the title compound as a colorless oil. Yield: 98.5%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-6191a2c387c643329175e189408ab5a6 |
| Source note | uspto-grants-2013_11 |