N-Hydroxy-3-trimethylsilyl-prop-2-ynimidoyl chloride → N-hydroxy-3-(m-tolyl)prop-2-ynimidoyl chloride

HRID 2040889Notes

Reaction equation

HRID 2040889 reaction equation
[OH:1][N:2]=[C:3]([Cl:10])[C:4]#[C:5][Si](C)(C)C.ON=CC#[C:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18](C)[CH:17]=1>>[OH:1][N:2]=[C:3]([Cl:10])[C:4]#[C:5][C:18]1[CH:17]=[C:16]([CH3:15])[CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 86662874N-Hydroxy-3-trimethylsilyl-prop-2-ynimidoyl chlorideHCID 86662876N-hydroxy-3-(3-methylphenyl)prop-2-yn-1-imine

Product 1

HCID 86662877N-hydroxy-3-(m-tolyl)prop-2-ynimidoyl chlorideYield 96.4%

Procedure

The title compound was prepared following the method herein described for Compound 3b, using Compound 91c instead of 3-trimethylsilylprop-2-ynal oxime. The residue was used in the next step without further purification. Yield: 96.4%.

Workup

  1. customThe residue was used in the next step without further purification

Sources & evidence

ORD record
ord-9aba6ff3f2f147f7b09a5ba1475bd47a
Source dataset
uspto-grants-2013_11
Patent number
US08580962B2

Reaction notes

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