HCID 57493780, compound → HCID 76384278, compound

HRID 2040891Notes

Reaction equation

Cl[C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH2:14][C:13]3([C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[C:16](=[N:23][O:24][CH3:25])[CH2:15]3)[O:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1.CC1[N:32]=C(C#CC2CC3(C4C(=CC=CC=4)C(=O)C3)ON=2)C=CC=1>>[CH3:25][O:24][N:23]=[C:16]1[C:17]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:13]2([O:12][N:11]=[C:10]([C:9]#[C:8][C:4]3[CH:3]=[CH:2][CH:7]=[C:6]([CH3:5])[N:32]=3)[CH2:14]2)[CH2:15]1

Participants

Reactant 2

HCID 57493780HCID 57493780, compound

HCID 76384212HCID 76384212, compound

Product 1

HCID 76384278HCID 76384278, compoundYield 82%

Procedure

The title product was obtained the method described for the compound of Example 84 starting from the Compound of example 93 instead of the compound of Example 83. After the usual work-up procedure, the residue was purified by means of automated flash chromatography (SP01®TM-Biotage; gradient Petroleum Ether-EtOAc from 95:5 to 1:1) to give the title compound as a yellowish oil. Yield: 82%.

Workup

customAfter the usual work-up procedure, the residue was purified by means of automated flash chromatography (SP01®TM-Biotage; gradient Petroleum Ether-EtOAc from 95:5 to 1:1)

Sources & evidence

ORD record: ord-c03cffa9628c49ae85d5bc3e6c5811b7
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08580962B2

Reaction notes

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