HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylidenespiro(3.3)heptane → 9-[(3-Chlorophenyl)ethynyl]-7-oxa-8-azadispiro[3.1.4.1]undec-8-ene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylidenespiro(3.3)heptane | HCID 57493859 | — |
| Reactant | 3-(3-Chlorophenyl)prop-2-ynal oxime | HCID 76543056 | — |
| Product | 9-[(3-Chlorophenyl)ethynyl]-7-oxa-8-azadispiro[3.1.4.1]undec-8-ene | HCID 56644647 | — |
Reaction Steps
The title compound was prepared following the procedure described for Compound 3c, using Compound 31e instead of Compound 3b and Compound 97a instead of Compound 3a. After the usual work-up procedure, the residue was purified by means of automated flash chromatography (SP01®TM-Biotage; Petroleum Ether-EtOAc 97:3; then DCM 100%) to give the title compound as a white-yellowish solid. Yield: 20.7%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-6b60da2d832d42e691bc85c490fc25fc |
| Source note | uspto-grants-2013_11 |