HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxaspiro[4.5]decan-8-one → HCID 57493861, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxaspiro[4.5]decan-8-one | HCID 567415 | — |
| Reactant | 1,1-Diethyl 4-oxocyclohexane-1,1-dicarboxylate | HCID 2776071 | — |
| Reactant | 8-Methylidene-1,4-dioxaspiro[4.5]decane | HCID 10953743 | — |
| Product | HCID 57493861 | HCID 57493861 | — |
Reaction Steps
The title compound was prepared following the method reported herein for Compound 31a. As starting material diethyl 4-oxocyclohexane-1,1-dicarboxylate replaced 1,4-dioxaspiro[4.5]decan-8-one. After the usual work-up procedure the residue was purified by means of automated flash chromatography (SP01®TM-Biotage; gradient Petroleum Ether-EtOAc from 1:0 to 8:2) to give the title compound as a colorless oil. Yield: 88.1%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-ce9b68e9d5184dab83e15f0b540b686b |
| Source note | uspto-grants-2013_11 |