HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxaspiro[4.5]decan-8-one → 3,4-Dihydro-4-methylene-1H-2-benzopyran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxaspiro[4.5]decan-8-one | HCID 567415 | — |
| Reactant | 8-Methylidene-1,4-dioxaspiro[4.5]decane | HCID 10953743 | — |
| Reactant | 3,4-dihydro-1H-2-benzopyran-4-one | HCID 12339648 | — |
| Product | 3,4-Dihydro-4-methylene-1H-2-benzopyran | HCID 11171052 | 69.8% |
Reaction Steps
This intermediate was prepared following the procedure described Compound 31a. As starting material isochroman-4-one replaced 1,4-dioxaspiro[4.5]decan-8-one. After the usual work-up procedure the residue was purified by means of automated flash chromatography (SP01®TM-Biotage; gradient Petroleum Ether-EtOAc from 1:0 to 0:1) to give the title compound as a colorless oil. Yield: 69.8%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-4dd68c44738e483d9dca3f6548686b8b |
| Source note | uspto-grants-2013_11 |