HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-1-piperazinecarbonyl chloride → [7-[2-(3-Chlorophenyl)ethynyl]-9-oxa-3,8-diazaspiro[4.4]non-7-en-3-yl]-pyrrolidin-1-yl-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-1-piperazinecarbonyl chloride | HCID 3016935 | — |
| Reactant | {3-[(3-Chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-en-7-yl}(4-methyl piperazin-1-yl)methanone | HCID 56644861 | — |
| Product | [7-[2-(3-Chlorophenyl)ethynyl]-9-oxa-3,8-diazaspiro[4.4]non-7-en-3-yl]-pyrrolidin-1-yl-methanone | HCID 57493783 | 72.8% |
Reaction Steps
The title compound was synthesized using the method described for the compound of Example 104, replacing 1-pyrrolidincarbonyl chloride for 4-methyl-1-piperazinecarbonyl chloride. After the usual work-up procedure, the crude was purified by means of automated flash chromatography (SP01®TM-Biotage; CHCl3-1.4N methanolic ammonia 100:0.5) to afford an ivory solid. Yield: 72.8%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-4e319a6d9090495681509550a98f0a33 |
| Source note | uspto-grants-2013_11 |