huagongshe.com
HRID2040907

反应详情

EQUATION

反应方程式

HRID 2040907 的结构方程式

REACTANTS

反应物

4
结构：CN=C=O
HCID12228

Methyl isocyanate

C2H3NO

结构：O=C(Cl)c1ccco1
HCID68242

2-Furancarbonyl chloride

C5H3ClO2

结构：NC(=O)N1CCC2(CC(C#Cc3cccc(Cl)c3)=NO2)C1
HCID56644646

未命名化合物

结构：Clc1cccc(C#CC2=NOC3(CCNC3)C2)c1
HCID57493822

未命名化合物

PRODUCTS

生成物

1
结构：O=C(c1ccco1)N1CCC2(CC1)CC(C#Cc1cccc(Cl)c1)=NO2
HCID57493793

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized following the method herein described for the compound of Example 96, but replacing Compound 22c for Compound 27d and 2-furoyl chloride for methylisocyanate. After the usual work-up procedure the crude was purified by means of automated flash chromatography (Isolera®TM-Biotage; gradient Petroleum Ether-EtOAc from 95:5 to 8:2) giving 105 mg of the title compound. Yield: 60.2%.

WORKUP

后处理

  1. customThe title compound was synthesized
  2. customAfter the usual work-up procedure the crude was purified by means of automated flash chromatography (Isolera®TM-Biotage; gradient Petroleum Ether-EtOAc from 95:5 to 8:2)