HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isocyanate → [2-[2-(3-Chlorophenyl)ethynyl]-4-oxa-3,8-diazaspiro[4.5]dec-2-en-8-yl]-(2-furyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | 2-Furancarbonyl chloride | HCID 68242 | — |
| Reactant | 3-[(3-Chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-7-carboxamide | HCID 56644646 | — |
| Reactant | 3-[(3-Chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene | HCID 57493822 | — |
| Product | [2-[2-(3-Chlorophenyl)ethynyl]-4-oxa-3,8-diazaspiro[4.5]dec-2-en-8-yl]-(2-furyl)methanone | HCID 57493793 | — |
Reaction Steps
The title compound was synthesized following the method herein described for the compound of Example 96, but replacing Compound 22c for Compound 27d and 2-furoyl chloride for methylisocyanate. After the usual work-up procedure the crude was purified by means of automated flash chromatography (Isolera®TM-Biotage; gradient Petroleum Ether-EtOAc from 95:5 to 8:2) giving 105 mg of the title compound. Yield: 60.2%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-ec249ce34d3444d68cd43b6b67052e08 |
| Source note | uspto-grants-2013_11 |