7-[2-(3-Chlorophenyl)ethynyl]-N-methoxy-N-methyl-9-oxa-3,8-diazaspiro[4.4]non-7-ene-3-carboxamide → HCID 57493794, compound

HRID 2040908Notes

Reaction equation

HRID 2040908 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH2:11][C:12]3([O:23][N:24]=2)[CH2:16][CH2:15][N:14]([C:17]([N:19]([O:21][CH3:22])[CH3:20])=[O:18])[CH2:13]3)[CH:5]=[CH:6][CH:7]=1.Cl[C:26]1C=C(C#CC2CC3(CCNC3)ON=2)C=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH2:11][C:12]3([CH2:16][CH2:15][N:14]([C:17]([N:19]([O:21][CH3:22])[CH3:20])=[O:18])[CH2:13][CH2:26]3)[O:23][N:24]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 574937997-[2-(3-Chlorophenyl)ethynyl]-N-methoxy-N-methyl-9-oxa-3,8-diazaspiro[4.4]non-7-ene-3-carboxamideHCID 574938223-[(3-Chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene

Product 1

HCID 57493794HCID 57493794, compoundYield 74%

Procedure

The title compound was synthesized using the method described for the compound of Example 110, replacing Compound 22c for Compound 27d. After evaporation, the crude was purified by means of automated flash chromatography (Isolera®TM-Biotage; gradient petroleum ether-EtOAc 8:2 to 6:4) to afford a pale yellow oil. Yield: 74%.

Workup

  1. customAfter evaporation
  2. customthe crude was purified by means of automated flash chromatography (Isolera®TM-Biotage; gradient petroleum ether-EtOAc 8:2 to 6:4)
  3. customto afford a pale yellow oil

Sources & evidence

ORD record
ord-65eb9ed77f5e43f98f861e9e676cece3
Source dataset
uspto-grants-2013_11
Patent number
US08580962B2

Reaction notes

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