HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-[2-(3-Chlorophenyl)ethynyl]-N-methoxy-N-methyl-9-oxa-3,8-diazaspiro[4.4]non-7-ene-3-carboxamide → HCID 57493794, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-[2-(3-Chlorophenyl)ethynyl]-N-methoxy-N-methyl-9-oxa-3,8-diazaspiro[4.4]non-7-ene-3-carboxamide | HCID 57493799 | — |
| Reactant | 3-[(3-Chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene | HCID 57493822 | — |
| Product | HCID 57493794 | HCID 57493794 | 74% |
Reaction Steps
The title compound was synthesized using the method described for the compound of Example 110, replacing Compound 22c for Compound 27d. After evaporation, the crude was purified by means of automated flash chromatography (Isolera®TM-Biotage; gradient petroleum ether-EtOAc 8:2 to 6:4) to afford a pale yellow oil. Yield: 74%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-65eb9ed77f5e43f98f861e9e676cece3 |
| Source note | uspto-grants-2013_11 |