Chloroform → 2-[2-(3-Chlorophenyl)ethynyl]-9-methoxy-4-oxa-3,7-diazaspiro[4.4]non-2-ene

HRID 2040915Notes

Reaction equation

HRID 2040915 reaction equation
[C:1]1([C:7]#[C:8][C:9]2[CH2:13][C:12]3([CH2:18][CH2:17][NH:16][CH2:15]C3)[O:11][N:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(C#CC2CC3(CCN(C([O:39][C:40](C)(C)C)=O)CC3)ON=2)C=CC=CC=1.COC1C(=C)CN(C(OC(C)(C)C)=O)C1.C(Cl)(Cl)[Cl:60]>>[Cl:60][C:5]1[CH:6]=[C:1]([C:7]#[C:8][C:9]2[CH2:13][C:12]3([CH:18]([O:39][CH3:40])[CH2:17][NH:16][CH2:15]3)[O:11][N:10]=2)[CH:2]=[CH:3][CH:4]=1

Participants

5

Reactant 4

HCID 6212ChloroformHCID 57493807Tert-butyl 3-(phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-8-carboxylateHCID 574938083-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-eneHCID 57493865Tert-butyl 3-methoxy-4-methylenepyrrolidine-1-carboxylate

Product 1

HCID 574938662-[2-(3-Chlorophenyl)ethynyl]-9-methoxy-4-oxa-3,7-diazaspiro[4.4]non-2-ene

Procedure

The title compound was synthesized following the method reported for the Compound 1c, substituting Compound 1b with the compound of Example 125 and using chloroform as the solvent. The crude residue was used without further purification in the next reaction.

Workup

  1. customThe crude residue was used without further purification in the next reaction

Sources & evidence

ORD record
ord-4e264960271a45ee8fa4355dde37d3cd
Source dataset
uspto-grants-2013_11
Patent number
US08580962B2

Reaction notes

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