HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → 2-[2-(3-Chlorophenyl)ethynyl]-9-methoxy-4-oxa-3,7-diazaspiro[4.4]non-2-ene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Tert-butyl 3-(phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-8-carboxylate | HCID 57493807 | — |
| Reactant | 3-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene | HCID 57493808 | — |
| Reactant | Tert-butyl 3-methoxy-4-methylenepyrrolidine-1-carboxylate | HCID 57493865 | — |
| Product | 2-[2-(3-Chlorophenyl)ethynyl]-9-methoxy-4-oxa-3,7-diazaspiro[4.4]non-2-ene | HCID 57493866 | — |
Reaction Steps
The title compound was synthesized following the method reported for the Compound 1c, substituting Compound 1b with the compound of Example 125 and using chloroform as the solvent. The crude residue was used without further purification in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-4e264960271a45ee8fa4355dde37d3cd |
| Source note | uspto-grants-2013_11 |