反应详情

温度

120 °C

An amount of 21.4 g (0.214 mol) of 2,2-difluoro-1-chloroethane and 20 g (0.107 mol) of potassium phthalimide are dissolved in 95 g of N,N-dimethylformamide. The reaction mixture is stirred in an autoclave under pressure at 120° C. for 12 h. After the end of the reaction, cooling is carried out to ambient temperature and the solvent is exhaustively removed under vacuum. The remaining residue is treated with 100 ml of water and the solid is filtered off. The filter residue is washed twice with water and the product is dried under vacuum. An amount of 22.5 g of 2-(2,2-difluoroethyl)-1H-isoindole-1,3(2H)-dione with a purity of only 59% is obtained. This corresponds to a yield of 59% of theory.

1. customAfter the end of the reaction
2. temperaturecooling
3. customis carried out to ambient temperature
4. customthe solvent is exhaustively removed under vacuum
5. additionThe remaining residue is treated with 100 ml of water
6. filtrationthe solid is filtered off
7. washThe filter residue is washed twice with water
8. customthe product is dried under vacuum