Vinyl Acetate → HCID 19809220, compound

HRID 2041337Notes

Reaction equation

HRID 2041337 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][C:5]([OH:7])=[O:6].[C:8](OC=C)(=O)[CH3:9]>C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[CH:8]([O:6][C:5](=[O:7])[CH2:4][CH2:3][CH2:2][Br:1])=[CH2:9]

Participants

4

Reactant 2

HCID 7904Vinyl AcetateHCID 758094-Bromobutyric acid

Product 1

HCID 19809220HCID 19809220, compound

Reagents, catalysts & solvents 1

HCID 167845palladium(II) acetateCatalyst

Procedure

To 4-bromobutyric acid (1.0 g, 6.0 mmol) in vinyl acetate (54 mL) add with stirring palladium(II) acetate (188 mg, 0.84 mmol) and continue stirring overnight at ambient temperature. Filter and concentrate in vacuo to provide the crude desired intermediate.

Workup

  1. filtrationFilter
  2. concentrationconcentrate in vacuo

Sources & evidence

ORD record
ord-48e4bbd0dbea4ea39880df13dc0ff408
Source dataset
uspto-grants-2013_11
Patent number
US08580780B2

Reaction notes

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