Hydrochloric Acid → HCID 66707021, compound

HRID 2041385Notes

Reaction equation

HRID 2041385 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:20][C:21](=O)N(C)C)=[C:16]([Cl:19])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.[Cl:26][C:27]1[S:28][C:29](CCl)=[CH:30][CH:31]=1.Cl>>[ClH:19].[Cl:19][C:16]1[CH:17]=[CH:18][C:11]2[CH2:10][CH2:9][NH:8][CH2:14][CH2:13][C:12]=2[C:15]=1[S:20][CH2:21][C:29]1[S:28][C:27]([Cl:26])=[CH:31][CH:30]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 5830792-Chloro-5-(chloromethyl)thiopheneHCID 576559793-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 66707021HCID 66707021, compound

Procedure

Use a method similar to the Example 387, using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 2-chloro-5-(chloromethyl)thiophene to give, after hydrochloride formation by the General Procedure 2-2, the title compound as a brown solid. MS (APCI+) m/z: 344 (M+H)+.

Workup

  1. customto give

Sources & evidence

ORD record
ord-13bd32125c0b40ed92ea941bcced1e10
Source dataset
uspto-grants-2013_11
Patent number
US08580780B2

Reaction notes

Loading…