Hydrochloric Acid → HCID 66706785, compound

HRID 2041399Notes

Reaction equation

HRID 2041399 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:20][C:21](=O)N(C)C)=[C:16]([Cl:19])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.[CH3:26][S:27]([C:30]1[CH:37]=[CH:36][C:33](CBr)=[CH:32][CH:31]=1)(=[O:29])=[O:28].Cl>>[ClH:19].[Cl:19][C:16]1[CH:17]=[CH:18][C:11]2[CH2:10][CH2:9][NH:8][CH2:14][CH2:13][C:12]=2[C:15]=1[S:20][CH2:21][C:33]1[CH:36]=[CH:37][C:30]([S:27]([CH3:26])(=[O:29])=[O:28])=[CH:31][CH:32]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 27335814-(Methylsulfonyl)benzyl BromideHCID 576559793-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 66706785HCID 66706785, compound

Procedure

Use a method similar to the Example 380, using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 4-methylsulfonylbenzyl bromide to give, after hydrochloride formation by the General Procedure 2-2, the title compound as a white solid. MS (ES+) m/z: 382 (M+H)+.

Workup

  1. customto give

Sources & evidence

ORD record
ord-18ee99f60d3342f897e38574c7ac599f
Source dataset
uspto-grants-2013_11
Patent number
US08580780B2

Reaction notes

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