HRID2041624

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13139

Diethyl phosphorochloridate

C4H10ClO3P

结构：COC(=O)NC(C(=O)NCCCCC(CO)N(CC(C)C)S(=O)(=O)c1ccc(N)c(F)c1)C(c1ccccc1)c1ccccc1

HCID24815407

未命名化合物

PRODUCTS

生成物

结构：CCOP(=O)(OCC)OC[C@H](CCCCNC(=O)[C@@H](NC(=O)OC)C(c1ccccc1)c1ccccc1)N(CC(C)C)S(=O)(=O)c1ccc(N)c(F)c1

HCID66791048

未命名化合物

PROCEDURE

实验过程

The product of step A was phosphorylated with chlorodiethylphosphate following the procedure described in example 1A, step G. Yields 157 mg, 68%.

WORKUP

后处理

customYields 157 mg, 68%

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f0a769e3b5e24d938fbeb42892770967
来源数据集: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08580995B2
来源说明: uspto-grants-2013_11

反应 SMILES

[CH3:1][O:2][C:3](=[O:45])[NH:4][CH:5]([C:19](=[O:44])[NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH:25]([N:28]([S:33]([C:36]1[CH:41]=[CH:40][C:39]([NH2:42])=[C:38]([F:43])[CH:37]=1)(=[O:35])=[O:34])[CH2:29][CH:30]([CH3:32])[CH3:31])[CH2:26][OH:27])[CH:6]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[CH3:46][CH2:47][O:48][P:49](Cl)([O:51][CH2:52][CH3:53])=[O:50]>>[CH3:1][O:2][C:3](=[O:45])[NH:4][C@H:5]([C:19](=[O:44])[NH:20][CH2:21][CH2:22][CH2:23][CH2:24][C@H:25]([N:28]([S:33]([C:36]1[CH:41]=[CH:40][C:39]([NH2:42])=[C:38]([F:43])[CH:37]=1)(=[O:34])=[O:35])[CH2:29][CH:30]([CH3:32])[CH3:31])[CH2:26][O:27][P:49]([O:51][CH2:52][CH3:53])([O:48][CH2:47][CH3:46])=[O:50])[CH:6]([C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1