Monomethylamine methanol → HCID 69673486, compound

HRID 2041876Notes

Reaction equation

C([O:3][C:4]([CH:6]([C:19]#[C:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:7][NH:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]=[CH:11][N:10]=1)=O)C.CO.[CH3:29][NH2:30]>O1CCCC1>[CH3:29][NH:30][C:4]([CH:6]([C:19]#[C:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:7][NH:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]=[CH:11][N:10]=1)=[O:3]

Participants

Conditions

Temperature: 60 °C

Procedure

130 mg of 4-[2-ethoxycarbonyl-4-phenyl-3-butynylamino]quinazoline and 3 ml of a 40% methylamine methanol solution were added to 5 ml of tetrahydrofuran, and the obtained mixture was stirred at 60° C. for 1 hour, and then at a room temperature over day and night. Thereafter, the reaction solution was concentrated, and the residue was then purified by flash chromatography (manufactured by Biotage AB; Isolera™), so as to obtain 113 mg of 4-[2-methylaminocarbonyl-4-phenyl-3-butynylamino]quinazoline.

Workup

waitat a room temperature over day
concentrationThereafter, the reaction solution was concentrated
customthe residue was then purified by flash chromatography (manufactured by Biotage AB; Isolera™)

Sources & evidence

ORD record: ord-ec03c6beafe6498295ec781ec447e3fc
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08586505B2

Reaction notes

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