1,3-Dichloroacetone → HCID 66995415, compound

HRID 2041902Notes

Reaction equation

HRID 2041902 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[C:4]([F:9])[CH:3]=1.C([Li])CCCCC.[Cl:17][CH2:18][C:19]([CH2:21][Cl:22])=[O:20]>C(OCC)C>[Cl:17][CH2:18][C:19]([C:2]1[CH:7]=[CH:6][C:5]([F:8])=[C:4]([F:9])[CH:3]=1)([OH:20])[CH2:21][Cl:22]

Participants

5

Reactant 3

HCID 107931,3-DichloroacetoneHCID 676754-Bromo-1,2-difluorobenzeneHCID 178506865HCID 178506865, compound

Product 1

HCID 66995415HCID 66995415, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Preparation according to Preparation 1: 1-bromo-3,4-difluorobenzene (5 g, 25.9 mmol), dry diethyl ether (100 mL), n-hexyllithium (2.3 M in hexane, 11.2 ml, 25.9 mmol) and 1,3-dichloroacetone (3.29 g, 25.9 mol). Yield: 4.54 g (73%). MS m/z (rel. intensity, 70 eV) 241 (M+, 1), 193 (32), 191 (bp), 141 (14), 127 (64).

Workup

  1. customPreparation
  2. customaccording to Preparation 1

Sources & evidence

ORD record
ord-0450c214bd2547028088ae775734d7ea
Source dataset
uspto-grants-2013_11
Patent number
US08586572B2

Reaction notes

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