Hexane → HCID 66995406, compound

HRID 2041903Notes

Reaction equation

HRID 2041903 reaction equation
Br[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([Cl:9])[CH:3]=1.C([Li])CCCCC.CCCCCC.[Cl:23][CH2:24][C:25]([CH2:27][Cl:28])=[O:26]>C(OCC)C>[Cl:23][CH2:24][C:25]([C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([Cl:9])[CH:3]=1)([OH:26])[CH2:27][Cl:28]

Participants

6

Reactant 4

HCID 8058HexaneHCID 107931,3-DichloroacetoneHCID 27362231-Bromo-3-chloro-5-fluorobenzeneHCID 178506865HCID 178506865, compound

Product 1

HCID 66995406HCID 66995406, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Preparation according to Preparation 1: 1-bromo-3-chloro-5-fluorobenzene (5 g, 23.9 mmol), dry diethyl ether (100 mL), n-hexyllithium in hexane (2.3 M, 10.4 ml, 23.9 mmol) and 1,3-dichloroacetone (3.03 g, 23.9 mol). Yield: 4.49 g (73%). MS m/z (rel. intensity, 70 eV) 257 (M+, 1), 209 (65), 207 (bp), 211 (11), 143 (28).

Workup

  1. customPreparation
  2. customaccording to Preparation 1

Sources & evidence

ORD record
ord-db22914065034fc2a5da2891d9064260
Source dataset
uspto-grants-2013_11
Patent number
US08586572B2

Reaction notes

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