反应详情

温度

120 °C

2-chloro-N-(4-(dimethylphosphoryl)phenyl)-9-vinyl-9H-purin-6-amine (0.05 g, 0.11 mmol) was dissolved in n-BuOH/DMSO (1.0 mL/0.2 mL) in a CEM 10 mL microwave tube and was added morpholine (95 □L, 1.1 mmol) and DIEA (96 □L, 0.55 mmol). The reaction was heated with microwave (120° C., 10 min). Solvent was removed on a rotavapor and the residue was partitioned between EtOAc/water, organic layer was separated and dried Na2SO4. The product was purified on ISCO combiFlash (12 g silica gel column, 5% MeOH/DCM) to yield the desired compound: MS [M+H]+ 559.

1. customSolvent was removed on a rotavapor
2. customthe residue was partitioned between EtOAc/water, organic layer
3. customwas separated
4. customThe product was purified on ISCO combiFlash (12 g silica gel column, 5% MeOH/DCM)