反应详情

A mixture of 0.4 g (1.01 mmol) of N-[6-chloropyridin-3-yl]-5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxamide, prepared in step 3.1, and 0.81 ml (10.06 mmol) of 3-hydroxypyrrolidine in 1.2 ml of N-methylpyrrolidinone is heated for 20 minutes in a microwave oven regulated at 200° C. under 300 watts. The reaction mixture is then poured into 50 ml of water. A solid is recovered by filtration and purified by silica column chromatography, elution being carried out with a mixture of dichloromethane and methanol. The resulting solid is then recrystallized from a mixture of methanol and dichloromethane. 0.22 g of a solid is recovered by filtration and dried under reduced pressure.

1. temperatureis heated for 20 minutes in a microwave oven
2. customregulated at 200° C. under 300 watts
3. filtrationA solid is recovered by filtration
4. custompurified by silica column chromatography, elution
5. additionbeing carried out with a mixture of dichloromethane and methanol
6. customThe resulting solid is then recrystallized from a mixture of methanol and dichloromethane
7. filtration0.22 g of a solid is recovered by filtration
8. customdried under reduced pressure