2-Methyl-3-nitro-6-(pyrrolidin-1-yl)pyridine → 2-Methyl-6-(pyrrolidin-1-yl)pyridin-3-amine

HRID 2041939Notes

Reaction equation

HRID 2041939 reaction equation
[CH3:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][CH:5]=[C:4]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[N:3]=1>[Pd]>[CH3:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[C:4]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[N:3]=1

Participants

3

Reactant 1

HCID 574315222-Methyl-3-nitro-6-(pyrrolidin-1-yl)pyridine

Product 1

HCID 574315232-Methyl-6-(pyrrolidin-1-yl)pyridin-3-amineYield 72.4%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The process is carried out according to the method described in step 5.2, using 0.55 g (2.65 mmol) of 2-methyl-6-(pyrrolidin-1-yl)-3-nitropyridine, prepared in step 9.1, and 0.1 g of 10% palladium-on-charcoal. 0.34 g of the expected product is thus obtained, which product will be used as it is in the rest of the synthesis.

Sources & evidence

ORD record
ord-a8094ab3430f4a3ca4f722388b6b2067
Source dataset
uspto-grants-2013_11
Patent number
US08586573B2

Reaction notes

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