2-(3-Azabicyclo[3.1.0]hex-3-yl)-5-nitropyridine → 2-(3-Azabicyclo[3.1.0]hex-3-yl)-5-aminopyridine

HRID 2041949Notes

Reaction equation

HRID 2041949 reaction equation
[CH:1]12[CH2:6][CH:5]1[CH2:4][N:3]([C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][N:8]=1)[CH2:2]2>[Pd]>[CH:1]12[CH2:6][CH:5]1[CH2:4][N:3]([C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][N:8]=1)[CH2:2]2

Participants

3

Reactant 1

HCID 574315302-(3-Azabicyclo[3.1.0]hex-3-yl)-5-nitropyridine

Product 1

HCID 574315312-(3-Azabicyclo[3.1.0]hex-3-yl)-5-aminopyridineYield 0.1%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The process is carried out according to the method used in example 5.2, using 0.2 g (0.97 mol) of 2-(3-azabicyclo[3.1.0]hex-3-yl)-5-nitropyridine, described in step 12.1, and 0.5 g of 10% palladium-on-charcoal. 0.1 g of the expected product is thus isolated, which product will be used as it is in the next step.

Sources & evidence

ORD record
ord-813bc2bd260a4ff4bb37c83f7e9b9058
Source dataset
uspto-grants-2013_11
Patent number
US08586573B2

Reaction notes

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