Hydrochloric Acid → 1146956-91-3

HRID 2041962Notes

Reaction equation

HRID 2041962 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11][CH:12]1[CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13]1)([CH3:4])([CH3:3])[CH3:2].[ClH:23]>O1CCOCC1>[ClH:23].[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11][CH:12]1[CH2:13][NH:14][CH2:15]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59577231HCID 59577231, compound

Product 1

HCID 685139381146956-91-3Yield 87%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a stirred solution of tert-butyl 3-(2-tert-butylphenylthio)azetidine-1-carboxylate (1.70 g, 5.29 mmol) in dioxane (5.0 mL) was added hydrogen chloride (5.3 mL of 4.0 M solution in dioxane, 21.2 mmol) at room temperature. After 24 h the reaction mixture was concentrated under reduced pressure and the resulting residue was triturated with diethyl ether to provide 3-(2-tert-butylphenylthio)azetidine hydrochloride (1.18 g, 87%) as a white solid.

Workup

  1. concentrationAfter 24 h the reaction mixture was concentrated under reduced pressure
  2. customthe resulting residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-5a2c41fddc9e479c8c2d3348046f272f
Source dataset
uspto-grants-2013_11
Patent number
US08586571B2

Reaction notes

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