2-Amino-4-chloropyrimidine → HCID 67252394, compound

HRID 2042066Notes

Reaction equation

HRID 2042066 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[F:8].Cl[C:11]1[CH:16]=[CH:15][N:14]=[C:13]([NH2:17])[N:12]=1>>[NH2:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[F:8])[O:9][C:11]1[CH:16]=[CH:15][N:14]=[C:13]([NH2:17])[N:12]=1

Participants

3

Reactant 2

HCID 2233322-Amino-4-chloropyrimidineHCID 135191803-Amino-4-fluorophenol

Product 1

HCID 67252394HCID 67252394, compoundYield 59.9%

Procedure

Using a procedure analogous to Example A3, 3-amino-4-fluorophenol (491 mg, 3.86 mmol) and 4-chloropyrimidin-2-amine (500 mg, 3.86 mmol) were combined to give 4-(3-amino-4-fluorophenoxy)pyrimidin-2-amine (509 mg, 59% yield). MS (ESI) m/z: 221.0 (M+H+).

Sources & evidence

ORD record
ord-4e41a0186e204bb7bee510d3b8f50d4f
Source dataset
uspto-grants-2013_11
Patent number
US08586565B2

Reaction notes

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