1,2-Difluoro-4-iodobenzene → 2-tert-Butyl-6-(3,4-difluoro-phenylethynyl)-pyrazolo[1,5-a]pyrimidine

HRID 2042162Notes

Reaction equation

HRID 2042162 reaction equation
[C:1]([C:5]1[CH:15]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[CH:14])=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[F:16][C:17]1[CH:22]=[CH:21][C:20](I)=[CH:19][C:18]=1[F:24]>>[C:1]([C:5]1[CH:15]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[C:14][C:20]3[CH:21]=[CH:22][C:17]([F:16])=[C:18]([F:24])[CH:19]=3)=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27244441,2-Difluoro-4-iodobenzeneHCID 583167022-tert-Butyl-6-ethynyl-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 532473322-tert-Butyl-6-(3,4-difluoro-phenylethynyl)-pyrazolo[1,5-a]pyrimidine

Procedure

The title compound, light yellow solid, MS: m/e=312.2 (M+H+), can be prepared in accordance with the general method of example 1 from 2-tert-butyl-6-ethynyl-pyrazolo[1,5-a]pyrimidine (example 21, step 2) and 1,2-difluoro-4-iodobenzene.

Sources & evidence

ORD record
ord-05151dc397894cc0871cfad246f6818b
Source dataset
uspto-grants-2013_11
Patent number
US08586581B2

Reaction notes

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