反应详情

7-Bromo-2,4-dichlorothieno[3,2-d]pyrimidine (1000 mg, 3.54 mmol) was dissolved in tetrahydrofuran-ethanol (1/1, 30 mL) and sodium borohydride (670 mg, 17.74 mmol) was added in several aliquots. The reaction mixture solution was cooled to room temperature and stirred for an hour. After adding water to terminate the reaction, the mixture solution was extracted with dichloromethane. The organic layer was washed with brine, dried with magnesium sulfate, and then concentrated. The yielded 7-bromo-2-chloro-3,4-dihydrothieno[3,2-d]pyrimidine (720 mg, 81% yield) was used without purification.

1. customto terminate
2. customthe reaction
3. extractionthe mixture solution was extracted with dichloromethane
4. washThe organic layer was washed with brine
5. dry with materialdried with magnesium sulfate
6. concentrationconcentrated