反应详情

温度

100 °C

7-Bromo-2-chlorothieno[3,2-d]pyrimidine (1.0 g, 4.03 mmol) was dissolved in 2.0 M ammonia isopropanol (10 mL) and stirred at 100° C. for 48 hours in a sealed reactor. The reaction mixture was cooled to room temperature and then concentrated. Purification by chromatography (50% ethyl acetate/hexane) yielded a brown solid compound (560 mg, 60% yield).

1. temperatureThe reaction mixture was cooled to room temperature
2. concentrationconcentrated
3. customPurification by chromatography (50% ethyl acetate/hexane)