2-Propanol, reaction products with ammonia, distn. residues → 7-Bromothieno[3,2-d]pyrimidin-2-amine

Participants

Reaction Conditions

Reaction Steps

7-Bromo-2-chlorothieno[3,2-d]pyrimidine (1.0 g, 4.03 mmol) was dissolved in 2.0 M ammonia isopropanol (10 mL) and stirred at 100° C. for 48 hours in a sealed reactor. The reaction mixture was cooled to room temperature and then concentrated. Purification by chromatography (50% ethyl acetate/hexane) yielded a brown solid compound (560 mg, 60% yield).

Provenance & Evidence