HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol → 3-(2-(6-(4-(2-Hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol | HCID 14479558 | — |
| Reactant | 3-(2-aminothieno[3,2-d]pyrimidin-7-yl)-N-methylbenzenesulfonamide | HCID 67120139 | — |
| Product | 3-(2-(6-(4-(2-Hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzenesulfonamide | HCID 52931896 | 53.7% |
Reaction Steps
3-(2-(6-(4-(2-Hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzenesulfonamide (18 mg, 53% yield) was prepared in the same manner as Step 10 of Example 1 using 3-(2-aminothieno[3,2-d]pyrimidin-7-yl)-N-methylbenzenesulfonamide (20 mg, 0.062 mmol) and 2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol (17 mg, 0.062 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586580B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-c0aa1cf7740f4a4d8ecfaf2e3869c442 |
| Source note | uspto-grants-2013_11 |