6-(4-Ethylpiperazin-1-yl)pyridin-3-amine → N-(3-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide

HRID 2042235Notes

Reaction equation

HRID 2042235 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5]2[S:10][CH:9]=[C:8]([C:11]3[CH:12]=[C:13]([N:17]([CH3:22])[S:18]([CH3:21])(=[O:20])=[O:19])[CH:14]=[CH:15][CH:16]=3)[C:6]=2[N:7]=1.[CH2:23]([N:25]1[CH2:30][CH2:29][N:28]([C:31]2[N:36]=[CH:35][C:34]([NH2:37])=[CH:33][CH:32]=2)[CH2:27][CH2:26]1)[CH3:24]>>[CH2:23]([N:25]1[CH2:26][CH2:27][N:28]([C:31]2[N:36]=[CH:35][C:34]([NH:37][C:2]3[N:3]=[CH:4][C:5]4[S:10][CH:9]=[C:8]([C:11]5[CH:12]=[C:13]([N:17]([CH3:22])[S:18]([CH3:21])(=[O:20])=[O:19])[CH:14]=[CH:15][CH:16]=5)[C:6]=4[N:7]=3)=[CH:33][CH:32]=2)[CH2:29][CH2:30]1)[CH3:24]

Participants

3

Reactant 2

HCID 91616746-(4-Ethylpiperazin-1-yl)pyridin-3-amineHCID 86673223N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide

Product 1

HCID 52932074N-(3-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamideYield 64%

Procedure

N-(3-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide (19 mg, 64% yield) was prepared in the same manner as Step 10 of Example 1 using N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide (20 mg, 0.57 mmol) and 6-(4-ethylpiperazin-1-yl)pyridin-3-amine (18 mg, 0.085 mmol).

Sources & evidence

ORD record
ord-3f062d95c9ed49ea946f3ef15829665f
Source dataset
uspto-grants-2013_11
Patent number
US08586580B2

Reaction notes

Loading…