HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(4-Ethylpiperazin-1-yl)pyridin-3-amine → N-(3-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(4-Ethylpiperazin-1-yl)pyridin-3-amine | HCID 9161674 | — |
| Reactant | N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide | HCID 86673223 | — |
| Product | N-(3-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide | HCID 52932074 | 64% |
Reaction Steps
N-(3-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide (19 mg, 64% yield) was prepared in the same manner as Step 10 of Example 1 using N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide (20 mg, 0.57 mmol) and 6-(4-ethylpiperazin-1-yl)pyridin-3-amine (18 mg, 0.085 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586580B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-3f062d95c9ed49ea946f3ef15829665f |
| Source note | uspto-grants-2013_11 |