3-Chloropropanesulphonyl chloride → 3-Chloro-N-(3-(2-chloro thieno[3,2-d]pyrimidin-7-yl)phenyl)propane-1-sulfonamide

HRID 2042240Notes

Reaction equation

HRID 2042240 reaction equation
[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[S:10][CH:9]=[C:8]([C:11]3[CH:12]=[C:13]([NH2:17])[CH:14]=[CH:15][CH:16]=3)[C:6]=2[N:7]=1.[Cl:18][CH2:19][CH2:20][CH2:21][S:22](Cl)(=[O:24])=[O:23]>>[Cl:18][CH2:19][CH2:20][CH2:21][S:22]([NH:17][C:13]1[CH:14]=[CH:15][CH:16]=[C:11]([C:8]2[C:6]3[N:7]=[C:2]([Cl:1])[N:3]=[CH:4][C:5]=3[S:10][CH:9]=2)[CH:12]=1)(=[O:24])=[O:23]

Participants

3

Reactant 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 866732143-(2-Chlorothieno[3,2-d]pyrimidin-7-yl)benzenamine

Product 1

HCID 866732263-Chloro-N-(3-(2-chloro thieno[3,2-d]pyrimidin-7-yl)phenyl)propane-1-sulfonamideYield 78.5%

Procedure

3-Chloro-N-(3-(2-chloro thieno[3,2-d]pyrimidin-7-yl)phenyl)propane-1-sulfonamide (240 mg, 78% yield) was prepared in the same manner as Step 7 of Example 1 using 3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)benzenamine (200 mg, 0.76 mmol) and 3-chloropropane-1-sulfonyl chloride (145 mg, 0.84 mmol).

Sources & evidence

ORD record
ord-a9052f787be24fdfaedfd9c938223db5
Source dataset
uspto-grants-2013_11
Patent number
US08586580B2

Reaction notes

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