Hydrochloric Acid → N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride

Participants

Reaction Steps

N-(3-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide (300 mg, 0.589 mmol) was dissolved in tetrahydrofuran (5 mL) and then 4 M hydrogen chloride (147 μL) dissolved in dioxane was added at room temperature. 30 minutes later, thus prepared precipitate was filtered and dried at room temperature. The target compound N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride (305 mg) was yielded.

Provenance & Evidence