反应详情

To a mixture of trans-tert-butyl-(4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexylcarbamate (0.49 g, 1.14 mmol) in dichloromethane (8 ml) was added at room temperature hydrochloric acid solution (4M in dioxane, 4.27 ml, 17.1 mmol) and the mixture was allowed to stir for 3 h, the solvent was evaporated, diethyl ether (20 ml) was added and the mixture was allowed to stir for 30 min at room temperature. The precipitate was collected by filtration, washed with diethyl ether and dried to yield the title compound as a white solid (0.5 g, 100%), MS (ISP) m/z=331.3 [(M+H)+], mp 287.5° C.

1. customthe solvent was evaporated
2. additiondiethyl ether (20 ml) was added
3. stirringto stir for 30 min at room temperature
4. filtrationThe precipitate was collected by filtration
5. washwashed with diethyl ether
6. customdried