Ethoxyacetic acid → HCID 178468083, compound

HRID 2042414Notes

Reaction equation

HRID 2042414 reaction equation
Cl.Cl.Cl.[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH:6]=[CH:5]1.[CH2:28]([O:30][CH2:31][C:32](O)=[O:33])[CH3:29]>>[CH2:28]([O:30][CH2:31][C:32]([NH:27][C@H:24]1[CH2:25][CH2:26][C@H:21]([CH2:20][CH2:19][N:16]2[CH2:17][CH2:18][N:13]([C:8]3[C:7]4[CH:6]=[CH:5][O:4][C:12]=4[CH:11]=[CH:10][N:9]=3)[CH2:14][CH2:15]2)[CH2:22][CH2:23]1)=[O:33])[CH3:29]

Participants

3

Reactant 2

HCID 12301Ethoxyacetic acidHCID 178478592HCID 178478592, compound2×

Product 1

HCID 178468083HCID 178468083, compound

Procedure

The title compound, white crystals (86 mg, 60%), MS (ISP) m/z=415.3 [(M+H)+], was prepared in analogy to example 4 starting from trans-4-[2-(4-furo[3,2-c]pyridin-4-yl-piperazin-1-yl)-ethyl]-cyclohexylamine trihydrochloride (intermediate A) (150 mg, 0.34 mmol) and ethoxyacetic acid (43 mg, 0.41 mmol).

Sources & evidence

ORD record
ord-1ab21597a0cc415db9c90642141fcf43
Source dataset
uspto-grants-2013_11
Patent number
US08586579B2

Reaction notes

Loading…