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HRID2042425

反应详情

EQUATION

反应方程式

HRID 2042425 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)CC1CCOCC1
HCID2773575

Tetrahydropyranyl-4-acetic acid

C7H12O3

结构：Cl.Cl.Cl.N[C@H]1CC[C@H](CCN2CCN(c3nccc4sccc34)CC2)CC1
HCID178478593

未命名化合物

2 次

PRODUCTS

生成物

1
结构：O=C(CC1CCOCC1)N[C@H]1CC[C@H](CCN2CCN(c3nccc4sccc34)CC2)CC1
HCID178520332

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in analogy to example 4 starting from trans-4-[2-(4-thieno[3,2-c]pyridin-4-yl-piperazin-1-yl)-ethyl]-cyclohexylamine trihydrochloride (intermediate B) (150 mg, 0.33 mmol) and tetrahydropyran-4-yl-acetic acid (50 mg, 0.35 mmol). Purification by flash chromatography on silica gel (CH2Cl2/MeOH 95:5). Off-white crystals (108 mg, 69%), MS (ISP) m/z=471.2 [(M+H)+].

WORKUP

后处理

  1. customPurification by flash chromatography on silica gel (CH2Cl2/MeOH 95:5)