Tetrahydropyran-4-ylacetic acid → HCID 178520332, compound

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Reaction Steps

The title compound was prepared in analogy to example 4 starting from trans-4-[2-(4-thieno[3,2-c]pyridin-4-yl-piperazin-1-yl)-ethyl]-cyclohexylamine trihydrochloride (intermediate B) (150 mg, 0.33 mmol) and tetrahydropyran-4-yl-acetic acid (50 mg, 0.35 mmol). Purification by flash chromatography on silica gel (CH2Cl2/MeOH 95:5). Off-white crystals (108 mg, 69%), MS (ISP) m/z=471.2 [(M+H)+].

Provenance & Evidence